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Tuberose.com
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This self-help alternative medicine site offers extensive educational information on the topics of natural healing, holistic and biological dentistry, herbal medicine, cleansing and detoxification, heavy metal detox, diet, nutrition, weight loss, and the finest, tried and tested health equipment and products available for the natural management of health. |
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Why do we need Probiotics?
Beneficial soil and plant based microbes used to be ingested as part of food grown in rich, unpolluted soil. However, for the last 50 years we have been sterilizing our soil with pesticides and herbicides, destroying most bacteria both bad and good. Our modern lifestyle, which includes antibiotic drug use, chlorinated water, chemical ingestion, pollution and poor diet, is responsible for eradicating much of the beneficial bacteria in our bodies. A lack of beneficial microbes often results in poor intestinal and immune system health, contributing to a wide range of symptoms and illnesses. The following symptoms may result from a lack of probiotics:
Gas, Bloating and Indigestion
Diarrhea and/or Constipation
Bad Breath and Body Odor
Candida Yeast Infections
Chronic Fatigue and Fibromyalgia
Parasites
IBS (Irritable Bowel Syndrome) Colitis
Crohn's Disease
Skin problems such as Acne, Eczema and Psoriasis
Delayed development in children
High Cholesterol Levels
Frequent Colds and Flu
The Age of Immunobiotics
Just one molecule can make the difference in modulating a healthy immune response. Surprisingly, it comes from bacteria. Twenty Nobel Prizes have been awarded for research on the immune response to harmful microbes. But in the grand scheme of things, bacterial infections are rare and opportunistic. Of the over 300,000 known bacterial species and possibly millions more, only about 170 are known to be pathogenic in mammals." In contrast, scientists are finally beginning to study and uncover the power of our friendly symbionts, the probiotics.
The two most-studied probiotics, that stand out as immune-modulating powerhouses—both the subject of hundreds of scientific, peer-reviewed studies are Lactobacillus GG and Saccharomyces boulardii, and the weight of new evidence in the last few years shows both to be profound immunobiotics with an ability to promote health far beyond the digestive tract.
Probiotics work best when they are used in a staged, multi-step fashion that specifically addresses each individual’s needs. The latest research shows that probiotics can protect against inflammation, arthritis, allergy, and infection. They shift immune response throughout the body. They are not just friendly bacteria. They are true immune modulators.
How Probiotics Can Shift Mood by Modulating Cytokines
From our early days in-utero until we die, the ability of the GI tract to renew and replenish itself and maintain a stable relationship with trillions of bacteria is astounding. On a typical day the innate immune system of our gastrointestinal tract will process more immunological information than the rest of our body in its entire lifetime. It’s an absolute immunological miracle we can consume antigenic particles of food and not drop down dead every time we do so.
In fact, the joy of modifying the gut mucosal immune system is that we can at the same time treat urinary, respiratory, inner ear and oral tissue. Gut originating immune molecules migrate out through the lymphatic tissue and influence the vagal nerve to deliver information systemically. Mucosal immunity is the key to gut health, overall immune balance, and even brain function and mood. Gut immunity and neuro-immunity are intimately bound, sharing the same receptors and the same signals. Information that initiates in the gut ends up in the brain and vice versa, providing a comprehensive cross talk between the two sets of tissues.
Tweaking the immune system through very careful use of targeted, strain specific probiotics is a novel and effective treatment for atypical depression—the most common subtype of depression and the form most commonly seen in women today. Many clinicians today consider probiotics in the same manner that medicine looked at antibiotics back in the 1950’s: with little regard for strain specificity, timing and dose. Timing, dosing, and delivery mechanisms of probiotics are key to their effective use.
The Gut-Brain Dialogue
So how in the world might probiotics—friendly gut organisms—treat depression? In a few words: cytokines, inflammation and immune response. Cytokines are messenger molecules that regulate our inflammatory and immune response. They operate continuously throughout our entire body and profoundly influence neuro-endocrine functioning. Depression has been linked with altered levels of cytokines like IL-1, IL-6 and TNFa, the inflammatory cytokine. Interleukin-1B is linked to dysthymia (low grade, chronic depression).
The gut-brain link was first seriously suggested by Dr. Julius Wagner-Jauregg, the only psychiatrist to have won a Nobel Prize back in 1927 (for medicine). He wrote; “Biological mediators primarily designed to combat pathogens may affect the course of psychiatric disorders.” Way before cytokines were discovered this clinician described how innate immune cytokines influence virtually every pathophysiological domain relevant to depression including monoamine neurotransmission, tryptophan metabolism, neuroendocrine function, synaptic plasticity and regional brain metabolism.
There is a well defined correlation between the severity of depression and the levels of TNFa. Patients suffering from chronic fatigue syndrome and sleep apnea will show excessive blood levels of TNFa. And when patients with cancer, multiple sclerosis, or hepatitis C are given interferons or interleukins as part of their treatment as many as 40% develop depression.
When animals are injected with molecules that stimulate cytokines, they become lethargic, fatigued, and anorexic. This is called “sickness behavior” and is associated with acute and some types of chronic infections.
The gut is a locus of many of these cytokines as the majority of our innate immune system is in the GI tract.
When the gut releases molecules signaling local infection, anxiety is enhanced—most likely through the vagus nerve. The vagus nerve provides a neural highway from the neurons of the gut right into the brain. Researchers inoculated mice with the intestinal bug Campylobacter jejuni, and found that vagal sensory neurons as well as the hypothalamus, amygdala and other important brain areas associated with anxiety and stress were activated. Infected animals also showed more cautious behavior. The authors conclude that treating infection and inflammation in the gut may help symptoms like anxiety and depression.
How Pathogens Sing the Blues
When our immune system encounters a gut pathogen, proteins on the pathogen’s surface bind to specialized receptors. Inflammatory cytokine chemicals such as IL-1, IL-6 TNFa and the chemokine IL-8 are triggered. These in turn stimulate the inflammatory regulator, NF Kappa B. This is necessary for an aggressive immune response that will help eradicate that pathogen. The immune system when healthy has a series of checks and balances to contain the damage and return to a neutral state after eradication. But in chronic low-grade gut infection, or dysbiosis, there may be persistently variably elevated cytokines. These impact mood in a waxing and waning manner.
Our gut biota is profoundly important to both immunity and mood. Our microbiota not only live with us, they carry an enormous skill set that helps us navigate life, from release of key nutrients to modulation of our immune system. We are a giant two-legged petri dish, more efficient at keeping our bacterial companions alive than any other medium on earth. To celebrate this unique ecological niche they provide a range of immune specific effects and help us to safely navigate a threatening world of pathogens and antigens.
In addition, serotonin levels can be impaired by chronic gut pathogens. Certain pathogens including bacteria, and viruses favor tryptophan as a primary fuel source. Reduced tryptophan means reduced levels of the feel-good neurotransmitter, serotonin.
The majority of serotonin receptors in the GI tract promote peristalsis—so, like many on SSRI’s, you may get diarrhea. In turn, the induction of inflammatory cytokines in response to increased levels of the pathogen will cause further mind-body disturbance by preventing the uptake of serotonin at the synapses because of inflammatory enzymatic binding.
There is an exquisitely complex dance of pathogens and the neuroendocrine and immune system. The common thread of chronic illness is persistent, low-grade inflammation and disturbed cytokine patterns.
A Little Help from My Friends
Probiotics, which by regulating cytokine levels in the gut, can influence infection and inflammation throughout the body, and even help balance brain function and mood. In recent years the interface between neuropsychiatry and gastroenterology has converged into a new discipline referred to as enteric neuroscience. Emerging studies have shown that intestinal bacteria can directly communicate with the central nervous system by way of the vagal sensory nerve fibers and the peripheral immune system. If we understand how potent a neuro-immune effect probiotics can have, we can use them in a stepwise fashion to tickle and coax our immune system into a state of tolerance and ideal, balanced responsiveness. And because the immune and nervous systems are intimately entwined, our brains will respond as well.
Think of probiotics as old friends—gentle protectors and supporters with whom you began your life’s journey. Your own personal microbiota is your own symphony, one that begins the moment you’re born (actually, it may even begin before you’re born, since the cord blood of caesarean born infants carries at least sixteen different species of bacteria). It is influenced by your diet, medications, your geography, and your genetics.
In ideal circumstances, you inherit healthy lactobacilli from your mother’s vaginal canal, and breastfeeding provides you with immunoglobulins, Bifido species and antibodies that help your gut lining mature properly, learning tolerance and balance. Those first months of your life may establish a ‘setpoint’ for immune susceptibility that is key to health. If you were born caesarean but breastfed, you will slowly catch up to your natural-born peers but it may take as long as two years. But if you were fed formula, your gut biota may not be ideal. You may be more likely to suffer from allergies or immune-related issues. Add in early and frequent antibiotic treatment and a diet of prebiotic-deficient, processed foods and you may now have a gut lining that was never given the opportunity to mature properly. Your core microbiota, which you will carry through your life, is essentially established by age two but has remarkable plasticity as well, responding both positively and negatively to medications and probiotics.
You can’t just take a handful of probiotic capsules containing variable strains and expect to regain your health. The principle function of a probiotic is as an immune modulator but some strains increase pro-inflammatory cytokines and others increase IL-10, the main immune inflammation controller.
In order for probiotics to work most effectively, the gut lining first needs to be matured through the selective use of probiotics that specifically stimulate SIgA (secretory Immunoglubulin A), and must then be exposed to key strain-specific probiotics. SIgA is the great, forgotten immunoglobulin. It is so beneficial to the GI tract. SIgA determines our ability to communicate to our immune system exactly what bacteria we are harboring and what to do about it. If you don’t have enough SIgA, you can consume probiotics forever and never transfer enough of their relevant information to the appropriate immune tissues in enough volume to impact health. SIgA and the T-regulatory family of cells work in a cooperative manner to maintain tolerance, yet SIgA requires bacteria in the mucosal lumen to be stimulated. The use of an anti-inflammatory, SIgA-promoting yeast species can be a valuable adjuvant to optimizing gastrointestinal immune tolerance.
The Treatment Plan
With atypical depression, typical features include: a tendency towards excessive sleep without feeling refreshed, cravings for carbohydrates, low energy, a feeling their limbs are heavy, poor response to SSRI’s, more often female, and highly sensitized to stress and relationship breakdowns.
SIgA, the predominant immunoglobulin in the body, and the key anti-inflammatory, immunomodulating molecule protecting our mucosa in the mouth, nose, lungs, gut, and vaginal tissue. If you give probiotics in a cavalier manner to someone who does not have enough SIgA, you won’t get a good clinical response because of diminished immune interpretation. In other words, the immune system does not process information from bacteria and pathogens as effectively as it needs to when levels of SIgA are low.
If we can improve an individual’s SIgA status, we will then see a change in how they respond to subsequent probiotics. I measure SIgA from a salivary sample, since it’s systemic across mucosal tissues. If SIgA is low, give Saccharomyces boulardii, which is superb at promoting SIgA and has hundreds of peer-reviewed studies demonstrating its safety and effectiveness. Begin with as little as ¼ capsule in children and ½ capsule in adults, because this probiotic is very potent. Saccharomyces boulardii helps the body break down carbohydrates more effectively, reduces gut candida and neutralizes clostridium difficile toxins A and B, thus improving mucosal barrier effectiveness. It also lowers inflammatory IL-8.
Garum Amoricum, has quite quick effects in the improvement of mood and sleep and really helps the patient to feel that a change is occurring. It can take a couple of months with probiotics getting the dose and timing correct to see any change in the pattern of mood and behavior.
Once SIgA levels are up, I add in Lactobacillus GG, another probiotic with hundreds of studies demonstrating its benefit. This probiotic is a standout because it is so well studied. No other probiotic except Saccharomyces boulardii comes close. LGG is a known inducer of anti-inflammatory cytokines in humans like IL-10. It also increases the production of regulatory T-cells, which help to maintain control over inflammation. LGG is a human-derived strain and using human strains (ones that have been isolated from the gut of a healthy human) is important because they are well recognized by the innate immune system receptors and are efficient at priming immunoregulation. They will, when used correctly, ameliorate mucosal inflammation in the gut, liver, synovium and brain. Both LGG and http://tuberosestore.com/sabo.html are the best studied and probably most effective probiotics we have today.
Also add in other human strains of lactobacillus and bifido species, as well as Vitamin D, proteolytic enzymes, and herbs, including, as required; artemisinin, black walnut, olive leaf, TOA-free uña de gato, and oregano to modify bacterial communities and help kill gut pathogens.
Go with the Gut
The gut influences the brain, and the brain influences the gut. This bi-directional perspective provides a fertile area for surprising insights into CNS pathologies that have until now proven highly elusive to effective treatment.
Lactobacillus GG
Lactobacillus GG (isolated as a unique strain of Lactobacillus rhamnosus) is the most prolifically researched probiotic in the world—over 400 studies have been published that document its remarkable immune-modulating properties.
This unique immunobiotic was isolated from a healthy human in 1985 by a team of two Tufts University researchers, Barry Goldin, M.S., Ph.D. and Sherwood L. Gorbach, M.D. They spent nearly a decade testing organisms until they discovered one that was a potent antimicrobial, survived stomach and bile acid, and was very, very sticky—it adhered well to the gut mucosa. Naming the organism Lactobacillus GG (LGG), after the first initials of their last names, Goldin reports that the organism was unique in the “white, almost milky creamy colonies it would form, probably because of a polysaccharide in the cell wall.”
LGG continues to be studied around the world. Researchers have recently uncovered new benefits of this probiotic strain far beyond digestive health, as well as deciphering the mechanisms by which this hardy organism inhibits pathogens and their toxins, and helps restore and re-set immune function.
Like the Vitamin C of probiotics, Lactobacillus GG is both the most researched and most trusted, safe, effective immune-boosting probiotic we know of.
Preventing Diarrhea
In 1987, Goldin, Gorbach and their colleague Chang published a study in The Lancet entitled Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. The infamously destructive toxin of C. difficile is the bacterium that causes a devastating and often recurrent diarrhea. When this super probiotic strain was given to suffering patients after a course of antibiotics, relapses were prevented. This probiotic also prevents a strain of E. coli that triggers acute diarrhea, gut hemorrhages and hemolytic uremia from causing destructive changes to tissue.
Pretreatment with LGG diminished the number of lesions and reduced the permeability of the gut mucosal cells. Only the live organism worked; heat-inactivated organisms were not effective. LGG has also proven effective in combating many other troubling gut pathogens. This probiotic inhibits Clostridium, Bacteroides, Pseudomonas, Staphylococcus, Streptococcus and Enterobacteria—yet does not inhibit other beneficial Lactobacilli. This strain of Lactobacillus inhibits the shedding of rotavirus in fecal samples from infected children. Adults with gut infections fare well with LGG also.
This particular strain of Lactobacillus—as well as Saccharomyces boulardii—helps prevent antibiotic-associated diarrhea. In addition, this probiotic reduced diarrhea associated with chemotherapy for colorectal cancer.
LGG Prevents Many Infections and Autoimmune Conditions
LGG heals more than the gut in infants and young children. It helps prevent eczema. When pregnant mothers take LGG, their newborns have less eczema. LGG can reduce atopic dermatitis in those newborns, as well as reduce the risk of allergy by half when given to expectant mothers and then to infants in their first six months of life.
This remarkable immunobiotic can also help prevent ear infections in infants. LGG and Bifidobacterium offer a safe means of reducing the risk of early acute otitis media and antibiotic use…during the first year of life.
LGG may be able to prevent strep throat. The invasive capacity of eight strains of group A Streptococci (GAS)—all resistant to Erythromycin—was significantly inhibited by LGG, both live and heat-killed. It has also cleared nasal passages in guinea pigs with allergic rhinitis.
LGG reduces arthritis—perhaps because allergic disorders involve perturbed skin and gut mucosa and dysregulation of the immune response.
This Lactobacillus strain, taken orally, along with other probiotics, actually reduces the amount of Staphylococcus aureus and beta-hemolytic streptococci in the nasal passages of humans. Yet the probiotics themselves do not colonize the nose. That suggests that LGG truly does have a body-wide immune-boosting effect.
LGG can help a liver damaged by alcohol. Only 30% of alcoholics develop alcoholic liver disease, and research suggests that bacterial endotoxins may be another key factor. Animals fed alcohol plus this particular probiotic had significantly less severe liver damage (alcoholic steatohepatitis) than those fed alcohol alone. The probiotic “reduced alcohol induced gut leakiness and significantly blunted alcohol-induced oxidative stress and inflammation in both intestines and the liver.
This immunobiotic denatures toxins, decreases the inflammatory response, and produces peptides that balance the immune response while limiting the destructive potential of many pathogens.
How Does LGG Work?
LGG has remarkable effects on inflammation and infection. Research shows that it is able to significantly blunt the amounts of inflammatory cytokines that pathogenic bacteria seem to trigger—such as TNF-alpha, interleukins, and myeloperoxidase. Remarkably, it downregulates inflammation not only in the gut, but in the intestine, liver, lung and blood. It also seems to reduce the invasive capacity of bacteria. As a result, it can be highly beneficial in a variety of inflammatory diseases and infections.
LGG suppresses inflammatory molecules triggered by E. coli infections. While E. coli triggered inflammatory chemokines (measured by PCR), LGG significantly suppressed them. The probiotic does this by suppressing specific inflammatory pathways.
LGG even seems to be able to remove toxins from solution. Toxins can be removed simultaneously by the probiotic, and a combination of probiotics enhances their removal ability. One mechanism by which LGG heals the gut and the immune system is by actually binding or denaturing bacterial toxins.
LGG Alters the Immune Response
Pathogens harm by invading tissue, releasing endotoxins, and stimulating a marked immune response which releases a flood of inflammatory molecules. Immunobiotics limit a pathogen’s ability to invade as well as damage our own cells, and they help reduce our inflammatory response, leading to an overall balance that is far healthier. This probiotic is a very effective immunobiotic, one that helps regulate our own immune response.
This unique organism is able to lessen the damaging response of T and B cells to the pathogen Campylobacter jejuni in mice. It can actually restore the liver enzyme alkaline phosphatase in cells damaged by the potent mycotoxin deoxynivalenol.
LGG helps limit the runaway inflammatory response in our body. NF-Kappa B is a key molecule that regulates the entire inflammatory cascade. Amazingly, LGG seems to be able to quiet the gene that transcribes and regulates production of NF-Kappa B.
LGG may be working at the very deep and fundamental level of gene activity and transcription, in part by inhibiting the NF-Kappa B signaling pathway.
LGG may help our gut mucosa defend itself by promoting protective responses. LGG reduced cell death in vitro and when given to live animals. The This kind of cell death may be a precursor to a potentially deadly condition seen in premature infants, where part of the bowel dies, and sometimes the infant dies as well.
LGG may augment first-line defense secretory IgA responses. SIgA is a first line of defense for all mucosa in the body. LGG proteins heal the gut lining. Two proteins, p40 and p75, produced by LGG promote epithelial integrity and help prevent oxidative damage and permeability.
LGG and other immunobiotics may activate specific T-cells (Peyer’s patches). Oral consumption of this immunobiotic helps protect against infection and inflammation as far away as the nose, ears, skin, lung or urinary tract. Specific IgE is reduced when consuming immunobiotics, and animal studies have shown protection against bronchial infection with H. influenza and Candida.
It Actively Restores Immune Balance
LGG, with its antimicrobial and immune-regulating ability, along with its extremely sticky, adhesive properties, offers an entirely new therapeutic strategy for combating allergic and infectious disease. Our gut microbiota have a powerful ability to prime immune regulation. From the moment we’re born, our immune system is regulated by our flora—which in turn is influenced by everything from our mothers’ microbiota, the mode of delivery (vaginal, which colonizes the baby with Lactobacilli; or caesarean, which does not), whether we are breast or bottle fed, and our diet and environment. Diet directly influences the diversity of the microbiota. Host-microbe cross-talk is key to maintaining immune tolerance and effectiveness.
Saccharomyces boulardii
Just as Lactobacillus GG is the most-studied bacterial immunobiotic in the world, Saccharmoyces boulardii (S. boulardii) is the best researched probiotic yeast, with nearly 300 peer-reviewed studies. Isolated from litchi fruit in the 1920’s, S. boulardii colonizes the gut within three days of oral consumption and disappears from stool within 5 days after discontinuation. New research confirms it as a first choice for preventing and treating traveler’s diarrhea, antibiotic-associated diarrhea, and C. difficile colitis, as well as helping improve Crohn’s disease, ulcerative colitis and irritable bowel syndrome.
Studies have shown that S. boulardii:
• Protects against gut pathogens
• Modulates the immune response
• Decreases inflammation in a wide range of disorders
• Inhibits bacterial toxins
• Enhances the gut’s natural enzymes and nutrient transporters
• Increases the most important gut immunoglobulin, Secretory IgA
Hello Good Yeast, Goodbye Diarrhea
It’s widely known that S. boulardii helps prevent and treat antibiotic-associated diarrhea (AAD) caused by pathogens such as Clostridium species, Staphylococcus aureus, Klebsiella, Candida and Salmonella. Mainstream as well as integrative medicine doctors often prescribe it along with antibiotics.
S. boulardii modulates host signaling pathways involved in intestinal inflammatory responses and blocks activation of inflammatory molecules called kinases. The yeast blocks activation of other key inflammatory molecules like NF-Kappa B.
In one study, S. boulardii slashed the risk of antibiotic-associated diarrhea by nearly 2/3. S. boulardii protects against the devastating C. difficile colitis. Various probiotics help prevent antibiotic-associated diarrhea, but only S. boulardii prevents and treats C. difficile-associated diarrhea.
S. boulardii is effective in preventing traveler’s diarrhea as well, of which 80% is caused by E. coli, Shigella or Salmonella species. A study of over 1000 travelers found that rates of diarrhea dropped from nearly 40% to 29% when travelers started taking S. boulardii at 1000 milligrams daily, five days before and for the duration of their trip.
Diarrhea in children, in patients on enteral feeding tubes, and in AIDS patients, also responds to S. boulardii. Even Crohn’s patients may benefit from S. boulardii. Those receiving S. boulardii experienced significant improvements in intestinal permeability. Other animal studies have shown that S. boulardii helps maintain the gut’s epithelial integrity and ameliorate inflammatory responses in the presence of various infecting pathogens.
Secretory IgA: The Critical Mucosal Immunoglobulin
Secretory IgA (SIgA) is our first line of defense against invading microbes and is key to maintaining mucosal homeostasis and integrity. It is the main immunoglobulin found in mucus, tears, saliva, vaginal fluid, and secretions from the intestine and lining of the lungs. It resists degradation by enzymes, and provides profound protection against pathogens. S. boulardii is uniquely able to stimulate SIgA.
A June 2009 study compared Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii. The study found that S. boulardii stimulated significantly higher levels of secretory IgA than the other organisms, and S. boulardii alone induced a higher level of the potent anti-inflammatory cytokine, Interleukin 10 (IL-10). S. boulardii can increase SIgA by as much as 56% in duodenal fluid, according to one study. SIgA nearly doubles when mice are fed S.b. and then exposed to C. difficile toxin. In germ-free mice, inoculation with S. boulardii increased total IgA.
S. boulardii is anti-inflammatory: it decreases the expression of inflammatory cytokines including interleukin 8 (Il-8), IL-6, IL-1b, tumor necrosis factor alpha (TNF-a) and interferon gamma (IFN-y). It may even decrease the number of T-cells producing IFN-y. S. boulardii can decrease IL-8 secretion from human colon cells after stimulation with a toxin from C. difficile. It can also reduce inflammation by suppressing nuclear factor-kappa B (NF-kB), which is activated during infection. In one study of human colon cells, S. boulardii inhibited NF-kB pathways after cells were exposed to a strain of E. coli that causes hemorrhage. Recent research shows that S. boulardii actually produces a specific low-molecular weight factor that directly blocks NF-kB activation.
S. boulardii also helps reduce levels of nitric oxide, which is associated with inflammatory bowel disease. It neutralizes bacterial toxins and inhibits toxin-binding to intestinal receptors as well as bacterial adhesion. In this way S. boulardii increases the gut’s integrity and helps protect it. It even increases the activity of enzymes like lactase and sucrase-isomaltase, helping aid digestion and absorption of nutrients from foods.
In a word, Saccharomyces boulardii restores intestinal homeostasis.
In the human gastrointestinal tract there are hundreds of microscopic life forms that live in a symbiotic relationship with one another. When the immune system breaks down, the body is left wide open for invasion of pathogenic organisms such as candida (yeast) and parasites. When taken on a daily basis, the HSO's set up a protective grid in the body and stimulate the immune system to ward off against all forms of bacteria, yeast, fungi and parasites. When HSO's colonize in the gastrointestinal tract here is simply no place for the pathogenic organisms to live. HSO's change the intestinal environment and can prevent the body from infestation of these dangerous organisms. Without HSO's, parasites and candida are free to wreak havoc in the digestive tracts of susceptible individuals.
Parasitic Infection (Parasites): Recent medical research suggests that 3 out of 5 Americans will be infected by parasites, at some point in their lives! Often going undetected, they live off of our bodies and reproduce rapidly. Parasites can rob the body of essential nutrients and can lead to serious illness or even death.
Candidiasis: Everyone has candida, a form of yeast that is normally found in the human digestive tract, the vagina, and on the skin. In healthy individuals with strong, functioning immune systems, it is harmless and kept in check by the beneficial bacteria occupying the same space. When the balance of intestinal bacteria is altered and the immune system becomes compromised, candida begins to proliferate, infecting organs and tissues. The candida becomes pathogenic, transforming from a simple benign yeast into an aggressive fungus that can severely compromise one's health.
The main component in Primal Defense is the HSOs, which have been used for over 22 years by thousands of health practitioners. The naturally occurring colony arrays of probiotics are non-mutated from the original cultures found in unpolluted soil and plants and are now cultured in U.S. laboratories using the discoverer's proprietary methods. The HSOs are in a substrate of nutrient rich superfoods providing vitamins, minerals, trace elements, enzymes and proteins. The probiotics are then made dormant using the Microflora Delivery System, which protects the probiotics and delivers them directly to the GI tract where they multiply and flourish.
Impervious to stomach acids and the digestive process, the microorganisms move through the stomach to the intestinal tract where they form colonies along the intestinal walls. HSOs multiply in the intestines and actually compete with harmful bacteria and yeasts for receptor sites, crowding out the pathogens and taking up residence. Once established, the organisms quickly begin producing the proper environment to absorb nutrients and help to re-establish the proper pH. According to early research and anecdotal evidence the following is a summary of the actions of HSOs:
HSOs work from the inside of the intestines dislodging accumulated decay on the walls and flushing out waste.
HSOs break down hydrocarbons, a unique ability to split food into its most basic elements allowing almost total absorption through the digestive system. This increases overall nutrition and enhances cellular development.
HSOs produce specific proteins that act as antigens, encouraging the immune system to produce huge pools of uncoded antibodies. This increased production of antibodies may significantly boost the body's ability to ward off diseases.
HSOs are very aggressive against pathological molds, yeasts, fungi, bacteria, parasites and viruses.
HSOs work in symbiosis with somatic (tissue or organ) cells to metabolize proteins and eliminate toxic waste.
HSOs stimulate the body to produce natural alpha-interferon. Alpha interferon is a potent immune system enhancer and a powerful inhibitor of viruses.
HSOs provide critical Lactoferrin supplementation. The microbes produce lactoferrin as a by-product of their metabolism. Lactoferrin is an iron binding protein essential for retrieving iron from foods.
Even if they manage to get through the destructive stomach acids, most probiotic supplements can have a hard time implanting in colons that are pH imbalanced or have too many harmful bacteria. HSOs are designed to implant in any colonic environment. The Microflora Delivery System makes sure that the probiotics colonize throughout the digestive tract where they can work their magic. The probiotics contained in Primal Defense are grown and incorporated into a living whole food substrate using the Poten-Zyme process. This puts the bacteria into their home, if you will, allowing them to thrive on their long journey through the GI tract. Most probiotics on the market today will grow bacteria and then, in a centrifuge, separate them from their substrate. We believe the substrate is as important as the probiotics themselves. Many probiotics have included fructooligosaccharides (FOS) in their product. FOS is an indigestible sugar that may cause digestive disturbances in certain individuals. Primal Defense contains no FOS. Since most probiotic supplements contain live cultures, they are temperature and age sensitive; therefore requiring refrigeration. If room temperature can begin to degrade these probiotics, imagine what the warm human body will do.
The HSOs are dormant in the caplet and activated by fluids. Primal Defense requires no refrigeration. Many probiotics on the market measure their potency in colony forming units (CFU). In Primal Defense, it's not the quantity of probiotics, it's the quality. The probiotics in Primal Defense are hardy and are designed to resist heat, cold, stomach acid, chlorine, fluorine, ascorbic acid and bile. The efficacy of a probiotic should be based upon the ability of the product to "on ferment" foods. If you want to test the viability of a probiotic product, simply drop a few caplets in 2-4 ounces of milk and leave at room temperature for 24-48 hours. If the probiotic is viable, the milk will change to a thick yogurt-like consistency. This measures the ability of a probiotic to produce enzymes and break down or pre-digest food. If a probiotic cannot pass this simple test, do you think it will be capable of doing its job in your body?
Primal Defense comes in two easy to use forms: Powder and caplets. UltraZorbe caplets utilize a proprietary technology which requires no heat and fully preserves the delicate probiotics and enzymes contained in the product. UltraZorbe caplets are designed to provide rapid disintegration and dissolution to completely deliver the nutrients in a timely fashion. Just drop a few caplets in water and see for yourself.
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